pentobarbital will lower the extent or effect of imatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Mysterious.pentobarbital will decrease the extent or influence of diltiazem by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Caution when discontinuing CYP3A4 inducers which have been c