pentobarbital will lower the extent or effect of imatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Mysterious.
pentobarbital will decrease the extent or influence of diltiazem by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Caution when discontinuing CYP3A4 inducers which have been coadministered with hydrocodone; plasma concentrations of hydrocodone may possibly improve and may result in perhaps fatal respiratory melancholy
pentobarbital will lower the level or result of pitolisant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Pitolisant exposure is reduced by 50% if coadministered with powerful CYP3A4 inducers.
pentobarbital will minimize the extent or result of irinotecan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will minimize the extent or result of tamoxifen by influencing hepatic enzyme CYP2C9/10 metabolism. Use Warning/Keep an eye on.
pentobarbital will lower the level or outcome of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration not suggested; sturdy cytochrome P450 enzyme inducers reduce systemic publicity to roflumilast and should reduce the therapeutic effectiveness
The efficacy of hormonal contraceptives may very well be diminished. Use another way of contraception or a backup process when enzyme inducers are utilised with put together hormonal contraceptives (CHCs), and proceed backup contraception for 28 days just after discontinuing enzyme inducer to guarantee contraceptive reliability.
pentobarbital will reduce the level or effect of docetaxel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unidentified.
pentobarbital will reduce the extent or effect of fentanyl transmucosal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of fentanyl with CYP3A4 inducers could lead into get more info a reduce in fentanyl plasma concentrations, lack of efficacy or, maybe, enhancement of the withdrawal syndrome inside of a patient who's got designed Bodily dependence to fentanyl.
pentobarbital decreases levels of elvitegravir/cobicistat/emtricitabine/tenofovir DF by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Could lead to lack of virologic reaction and feasible resistance.
pentobarbital will lower the extent or impact of eucalyptus by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Mysterious.
Coadministration of zuranolone with other CNS depressants could improve impairment of psychomotor functionality or CNS depressant effects. If unavoidable, look at dose reduction. .
pentobarbital will decrease the extent or result of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unfamiliar.